Improved myocardial viability following intramyocardial autologous bone marrow injection after acute myocardial infarction

Autologous bone marrow stem cell transplant in acute myocardial infarction.

OBJECTIVE To evaluate the effects of autologous bone marrow stem cell transplant on clinical symptoms, overall left ventricle ejection fraction and myocardial perfusion in patients with recent anterior myocardial infarction in left anterior descending artery territory. METHODS The study was conducted in the department of interventional cardiology of Armed Forces Institute of Cardiology, Natio...

Myocardial perfusion and viability scintigraphy for assessment of the effect of intracoronary injection of autologous bone marrow cells in acute myocardial infarction

Improving myocardial viability: clinical implications for the use of bone marrow-derived stem cell infusion after acute myocardial infarction

The treatment of acute myocardial infarction (AMI) has evolved substantially over the past three decades, after an improvement in the mortality rate of AMI due to thrombolytics [1,2] and primary percu taneous intervention for coronary reperfusion [3]. Less than a decade ago, initial reports on the clinical application of mono nucleated bone marrow-derived stem cells (BMCs) in patients with AMI ...

Repair of Old Myocardial Infarction by Intracoronary Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells: A Pilot Clinical Trial

Experimental and clinical studies have shown that intracoronary transplantation of autologous bone marrow mesenchymal stem cells (BMSCs) has resulted in regenerated infarcted myocardium and improved left ventricular (LV) function. <span style="font-variant: normal; font-style: normal; f...

Intramyocardial Injection of Autologous Bone Marrow Cells as an Adjunctive Therapy to Incomplete Myocardial Revascularization - Safety Issues

OBJECTIVES To determine the safety of intramyocardial injection of autologous bone marrow cells in patients undergoing surgical myocardial revascularization (CABG) for severe coronary artery disease. INTRODUCTION There is little data available regarding the safety profile of autologous bone marrow cells injected during surgical myocardial revascularization. Potential risks include arrythmias,...